On Wednesday, February 5, at 17:30 GMT+2 we will hear two talks on #Aging Research:

Talk 1

Dr. Robi Tăcutu, "Bioinformatics in aging research at the Institute of Biochemistry", Biochemistry of the Romanian Academy, Bucharest

Keywords: Aging Research, Longevity Prediction, OMICs Data, Bioinformatics Tools

Abstract: Aging is a gradual and degenerative process characterized by both physiological and pathological changes. In today's research landscape, an abundance of large-scale OMICs data is available, accompanied by a plethora of bioinformatics tools designed to handle such datasets. A crucial challenge remains: the integration and analysis of these datasets to both predict the health status of a biological system and also to suggest interventions that can rejuvenate and enhance its health. In this talk, we will describe some of the analyses, databases, and tools developed at the Institute of Biochemistry that are specifically tailored for gerontology research.

Resources: https://www.biochim.ro/researchers-staff/robi.tacutu/

Talk 2

Eugen Ursu, "Ageing and intercellular communication", Biochemistry of the Romanian Academy, Bucharest

Keywords: Aging and Cell Communication, Single-Cell Transcriptomics, Tissue Aging

Abstract: The loss in cell-to-cell communication is a key feature of aging. To better understand and measure these changes, we have developed two tools, scDiffCom and scAgeCom. scDiffCom is a software package that uses known interactions between signaling molecules and their receptors to analyze differences in cell communication from single-cell transcriptomics data. Building on scDiffCom, scAgeCom provides a detailed map of how cell communication changes with age and sex, covering 23 different mouse tissues and using data from 58 single-cell RNA sequencing studies. This helped us identify key changes in communication during aging, such as the upregulation of immune system processes and inflammation, the downregulation of developmental processes, angiogenesis and extracellular matrix organization, and the deregulation of lipid metabolism. scAgeCom is available online for researchers and the public at https://scagecom.org.

Format: Online, free to attend, no registration is required: Zoom

Organization: YMS is organized by RSBI and is linked to RoBioinfo Seminars

Click here to subscribe for upcoming #RSBI Events

Check all bioinformatics events on CRB website